Manufacturing process of 2-aminothiazole storage method. It is an improvement on the existing hot sodium process. Metallic sodium is dissolved in organic solvent, and then pyridine is added under nitrogen protection for sodium reaction. It then passes through the oxidizing agent for oxidation. Then, the organic solvent and pyridine were recovered by vacuum distillation, and the residual liquid was extracted with ethyl ether. The solvent was dried by anhydrous sodium sulfate and then evaporated at atmospheric pressure to obtain the 4,4'-2-aminothiazole storage method. Its characteristics are as follows :a, the organic solvent uses hexamethylphosphotriamine; b, during the natritization reaction, the molar ratio of pyridine and metallic sodium is 1:1 -- 5:1, the reaction temperature is 20 -- 100℃; c, the oxidizer is oxygen, air, air/oxygen mixture gas. The invention has the advantages of short reaction period, high yield and simple process.
White or light pink crystalline powder. mp69.7℃; bp272 ~ 273℃. Soluble in ethanol, ether, benzene, trichloromethane, petroleum ether, soluble in about 2000 parts of water, its solution is red when it meets ferrite salt.
Mixing anhydrous pyridine with anhydrous ferric chloride, heating reaction, cooling solidification to obtain red black crystal. Excess pyridine is removed by steam heating. Steam 2,2' -bipiridine. Add sodium hydroxide with ether as solvent, remove ether, get crude product. White blade-like crystal was obtained by decolorization and filtration of iron-free activated carbon, which was pure 2,2 'monopyridine.
Main products include
COF, MOF monomer series: tripterene derivatives, amantadane derivatives, tetraphenylene methane derivatives, polyamine series, polyaldehyde series, 2-aminothiazole storage method derivatives, porphyrin derivatives, phenylacetylene derivatives, etc. Control agent dye; Apis and intermediates; OLED photoelectric material monomer series: conjugated benzene derivatives, carbazole, thiophene, benzofuran and perylene/naphthalene anhydride derivatives, etc. Polyimide series: polyimide, diamine and dianhydride; Organosilicon series: monomer, reductant, protective agent and coupling agent; Small liquid crystal molecules can be photopolymerized.
2-aminothiazole storage method https://www.clentpharma.com/2-Aminothiazole.html
